function
DNA supercoiling, control of [category|SW 3.1.1|replication] initiation
product
DNA gyrase (subunit A)
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.3|DNA condensation/ segregation][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]Gene
Coordinates
6,994 → 9,459
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
ATP-dependent breakage, passage and rejoining of double-stranded DNA (according to Swiss-Prot)decreases [protein|6740108089F13116F200C15F35C2E7561E990FEB|DnaA] association with the oriC and inhibits [category|SW 3.1.1|replication] initiation [pubmed|29396913]Protein family
topoisomerase IIA gyrA/parC subunit family (according to Swiss-Prot)Paralogous protein(s)
[protein|9075DD0CC0B8554F0379732453665F43C70EFC26|ParC]Structure
[PDB|4DDQ] (DNA gyrase A-subunit lacking the C-terminal DNA-wrapping domains) [Pubmed|23602808][SW|Localization]
Nucleoid (Homogeneous) [Pubmed|16479537]nucleoid-associated in actively growing cells [Pubmed|9539793]Additional information
subject to Clp-dependent proteolysis upon glucose starvation [Pubmed|17981983]Expression and Regulation
Operons
genes
[gene|FB1C21A94697E5B9D29C0F3B9C9F36E57BCBD237|yaaA]-[gene|EBE03AEC7EC594A3115A7A72194BDFF300AA0BFA|recF]-[gene|CBC76FB453569550F14FE5015C05D45985C04979|remB]-[gene|AA42910B71348EFEA4165CFFCEF1E497897B9DDC|gyrB]-[gene|B207C7328177924B16F1C606F667BEADF12CA069|gyrA]
description
[Pubmed|22383849]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|2987848], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]view in new tabLabs working on this gene/protein
[SW|Dagmar Klostermeier], University of Münster, Germany, [http://www.biozentrum.unibas.ch/klostermeier/index.html homepage]References
16479537,17981983,9539793,2987848,19666507,17320901,23475963,23602808,20870749,24563461,27557712,27793284,12767818,6282812,29396913 
